Modifying Enzymes
Abcam beta-Lapachone, Topoisomerase I inhibitor, 50MG
MW 244.28 Da, Purity >98%. Topoisomerase I inhibitor. Inhibits topoisomerase I induced DNA cleavage. Induces apoptosis via a p53 independent mechanism. Shows antitumor, antiviral, antibacterial, antifungal and wound healing activities.
The product is subject to the following: Abcam Restricted Use Statement
Amsbio LLC Heparanase Assay Kit Positive Control Enzyme
Measure enzyme activity of heparanase in cell culture supernatants, human plasma, biological fluids and tissue samples. These kits provide a solution to the performance and standardization problems found with traditional measurement techniques used for these types of enzymes.
Medchemexpress LLC TC-Mps1-12 | 1206170-62-8 | 99.8% | 324.38 | 100 MG
TC-Mps1-12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor, with an IC50 of 6.4 nM. It inhibits the growth of pMps1 cell lines and A549 cells in a dose-dependent manner, exhibiting good pharmacokinetic properties.
- Potent and selective Mps1 inhibitor
- Inhibits the growth of pMps1 cell lines with IC50 values of 131 nM in autophosphorylation assay
- Inhibits the growth of A549 cells in a dose-dependent manner in vivo, showing 47% tumor growth inhibition at 100 mg/kg without body weight loss
- Exhibits good PK properties with a Cmax of 3542 ng/mL and AUC of 6604 ng h/mL at an oral dose of 25 mg/kg
Sigma Aldrich Fine Chemicals Biosciences Proteinase from Aspergillus melleus Type XXIII, >=3 units/mg solid | 9001-92-7 | MFCD00132092 | 5G
Proteinase from Aspergillus melleus Type XXIII, >=3 units/mg solid | 9001-92-7 | MFCD00132092 | 5G
Medchemexpress LLC ADAMTS-5 Inhibitor 50mg | 929634-33-3 | 449.92 g·mol⁻¹ | C16H11ClF3N3OS3 | 50 MG
ADAMTS-5 Inhibitor is a small-molecule research compound that potently inhibits ADAMTS-5 (aggrecanase-2) with an IC50 of 1.1 μM and shows >40-fold functional selectivity over ADAMTS-4. It is supplied as a solid with a reported purity of 99.59%, a molecular weight of 449.92 g·mol⁻¹, and formula C16H11ClF3N3OS3. For research use only.
- Potent ADAMTS-5 inhibition (IC50 1.1 μM).
- Greater than 40-fold functional selectivity over ADAMTS-4.
- High reported purity of 99.59%.
- Supplied as a solid; also available as a 10 mM solution in DMSO.
- Available in multiple milligram packaging options (5 mg-500 mg) and larger quantities on request.
- Intended for research use only.
![Amsbio LLC Neuraminidase [Sialidase]; Acylneuraminyl hydrolase [EC 3.2.1.18]](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502566247.png-250.jpg)
Amsbio LLC Neuraminidase [Sialidase]; Acylneuraminyl hydrolase [EC 3.2.1.18]
Neuraminidase [Sialidase]; Acylneuraminyl hydrolase [EC 3.2.1.18]
Cayman Chemical Oleoyl-L-carnItIn-d3chlorI 5mg
An internal standard for the quantification of oleoyl-L-carnitine by GC- or LC-MS
Cayman Chemical Monoacylglycerol Lipase FL P
Immunogen: Purified recombinant human MAGL • Host: Rabbit • Species Reactivity: (+) Human and rat; other species not tested • Applications: ICC, IHC, and WB
ABclonal Technology Acetyl-CoA Carboxylase
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA the rate-limiting step in fatty acid synthesis There are two ACC forms alpha and beta encoded by two different genes ACC-alpha is highly enriched in lipogenic tissues The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA Multiple alternatively spliced transcript variants divergent in the 5 sequence and encoding distinct isoforms have been found for this gene
Apexbio Technology LLC EZ Cap OVA mRNA (5-moUTP) 5x1mg (1mg/mL)
Ovalbumin (OVA) mRNA encodes a egg white glycoprotein with a molecular weight of approximately 45 000 daltons It can induce moderate immunogenicity in organisms and is commonly used as an immunogen in immunological experiments such as establishing animal models for hypersensitivity asthma etc EZ Cap OVA mRNA (5-moUTP) is provided at 1 mg/mL capped by co-transcriptional capping with a Cap 1 structure and polyadenylated Modified 5-moUTP incorporation reduces the host cell immune response and enhances mRNA stability and translation efficiency
INTACT GENOMICS INC Exonuclease III 25000 Units (100 units/µl)
Exonuclease III (Exo III) is an exodeoxyribonuclease that digests one strand of duplex DNA from a blunt end, 5′ overhang or nick. The enzyme acts in a 3′→5′ direction producing stretches of single-stranded DNA (1, 2). Exo III is not active on 3′ overhangs of 4 or more bases in length and ssDNA. The enzyme has also RNase H, 3′-DNA phosphatase, and apurinic DNA endonuclease activities. Exo III digestions proceed at a uniform rate yielding predictable and reproducible results. However, the observed rate of nucleotide excision can vary depending on the individual characteristics of the reaction mix such as reaction temperature, ionic strength, template base content, template helical structure, and enzyme-to-DNA ratios.Applications• 3′ → 5′ exonuclease• Production of unidirectional nested deletions• Production of intermediates for site-directed mutagenesis• Preparation of strand-specific probes• Preparation of single-stranded substrates for dideoxy sequencing
Cayman Chemical Oleoyl SerotonIn-d17 1mg
An internal standard for the quantification of oleoyl serotonin by GC- or LC-MS
ABclonal Technology T4 DNA Ligase (High Conc.)
T4 DNA Ligase catalyzes the formation of a phosphodiester bond between juxtaposed 5 phosphate and 3 hydroxyl termini in duplex DNA or RNA. This enzyme will join blunt end and cohesive end termini as well as repair single stranded nicks in duplex DNA and some DNA/RNA hybrids. T4 DNA ligase will seal nicks for these DNA substrates. T4 DNA Ligase is applicable to cloning of restriction fragments and to joining linkers and adapters to blunt-ended DNA.